Project 1: Clinical investigation of the effects of micronutrients and bioactive compounds in the prevention and treatment of diseases.
Project description: The project aims to investigate the effects of micronutrients and bioactive compounds in molecular, cellular, genetic, and biochemical mechanisms of processes related to different conditions in health and disease. This project involves diagnostic studies and/or nutritional and dietary intervention in healthy and sick animal and/or human models in different life cycles.
Project 2: Nutritional aspects in Lipodystrophy Syndrome in HIV/AIDS patients.Project description: The systemic effects of oxidative stress and inflammation mediated by chronic HIV infection and the toxicity of antiretroviral drugs contribute to metabolic disorders that require dietary and nutritional treatment. The project aims to carry out basic and clinical research involving investigating body composition, energy, and micronutrient metabolism of HIV-seropositive patients with lipodystrophy secondary to the use of antiretroviral drugs through the use of metabolic, molecular, inflammatory, and genetic markers.
Project: Evaluation of the genetic and biochemical profile in obesity and patients undergoing bariatric surgery.Project description: Conduct clinical studies on nutritional outcomes using genetic, molecular, and biochemical markers in patients with obesity and undergoing surgical treatment.
Project: Eating behavior of healthy and sick individuals.Project description: The project aims to understand aspects related to or influencing the eating behavior of healthy and sick individuals, with two main focuses: hospitalized and those with obesity through diagnostic and intervention studies, in the search for a new approach and nutritional treatment.
Research Group: Center for Studies, Research and Extension in Obesity and Eating Behavior – NEPOCA. Instagram page: @nepoca.fmrp.usp
Project: Nutritional epidemiology studies.
Studying the extent and distribution of nutritional disorders and their determinants in the population. It includes studies on the development and validation of methods for assessing food consumption, investigating the relationship between diet, nutritional status, disease prevention and control, and assessing the impact of nutritional guidelines aimed at health promotion.
Project:Intermediate metabolism and body composition under special clinical conditions, using stable (non-radioactive) isotopes.Project description: The project aims to develop stable isotope tracers in clinical practice, as well as stable isotopes and isotope ratio mass spectrometry in the study of energy and protein metabolism, body composition analysis, nutrient absorption, and Helicobacter pylori infection in special clinical conditions (first days of life, aging, frailty syndrome, cachexia, and HIV infection).
Project: Predictive value of the quantification of visceral and bone adiposity on bone mineral density.
The project aims to evaluate etiopathogenic, biochemical aspects, and qualitative and quantitative changes in bone tissue, relating them to visceral adiposity and deepening the interactive role between bone and adipose tissue in the regulation of energy and mineral metabolism through clinical and/or experimental studies..
Project 1: Studies on nutrigenomics.
The project aims to evaluate the gene-nutrient interaction to understand the relationship between health and diseases under the influence of the environment, food consumption and physical activity, using genomic, proteomic, and metabolomics tools in children and adolescents under different clinical conditions.
Project 2: Nutritional survey studies on child and adolescent health.
The objective of this project is to develop, validate, and evaluate the reproducibility of tools for a nutritional survey applied to clinical and population studies for children and adolescents.
Project 1: Nutritional and metabolic assessment of newborns.
The project aims to understand the relationship between the intrauterine growth restriction and the body composition of newborns in the first days of life and their mothers. Methods to assess the nutritional status of newborns, suitable for field studies and based on stable isotopes, will be developed.
Project 2: Nutritional Research on Inborn Errors of Metabolism.
The project aims to describe the incidence of hereditary metabolic diseases, nationwide, carry out studies with expanded neonatal screening using new technologies such as tandem mass spectrometry and, from the perspective of systemic biology, develop studies on the molecular biology of metabolic diseases and translational studies (genomics, proteomics, metabolomics, transcriptomics).
Project: Nutritional aspects in dementia and cognitive disorders in the elderly.
The objectives of the project are to know the incidence, etiologies, and socio-demographic distribution of dementia in the population of São Paulo and Ribeirão Preto, outline the cognitive and functional profile of the elderly population, describe risk factors associated with cognitive impairment, and investigate nutritional aspects involved in dementia and associated with the aforementioned variables. Clinical and epidemiological studies will be carried out.
Project: Clinical, metabolic, molecular, and experimental investigation of pathophysiology, diagnosis, and treatment of nutritional diseases
To perform diagnosis and therapy of diseases that directly or indirectly compromise the nutritional status and analyze the factors that influence the metabolism of macro and micronutrients in healthy people, clinical studies and investigations will be carried out involving stable isotopes and mass spectrometry.
Project: Metabolic effects of omega-3 fatty acid in situations of insulin resistance.
This project aims to investigate the effect of fatty acids on the metabolic regulation of patients with insulin resistance due to the excessive accumulation of lipids in adipose and liver tissue common in chronic and subclinical inflammation caused by changes in inflammatory cells, biochemical markers of inflammation, and endoplasmic reticulum stress activation (ERE). For this, we intend to evaluate in two models of insulin resistance (type 2 diabetes mellitus and obesity), through clinical and experimental studies, the effect of treatment with omega-3 on insulin sensitivity on the subclinical inflammatory process, in the control of glucose and lipid metabolism, and in the activation of the ERE. It is assumed that omega-3 fatty acid modulates the gene expression of transcription factors such as PPAR and NFkB, contributing to reduce the inflammatory process and insulin resistance.
Project: Multidimensional assessment of elderly patients.
Aiming to understand the aging processes, the etiopathogenesis of associated diseases, pathophysiology involving frailty and cognitive deterioration of the elderly, focusing on biological processes, clinical aspects of senescence and senility, and social consequences, aiming at various interventions, which can be applied in the care of the elderly, at the national level.
Project: Investigation of nutritional status, energy metabolism, oxidative and inflammatory stress in different pathological conditions.
These are studies involving the assessment of changes in nutritional status in different chronic diseases, particularly in chronic kidney disease and renal replacement therapy and cancer, from different markers of body composition and biochemicals, prioritizing nutritional and interventions with diet therapy.
Research Project:: Sociocultural and biological interrelations implied in contemporary food behavior and practices.Project description: This project aims to study contemporary phenomena related to food and nutrition and their consequences from an anthropological, psychosocial, biological, and nutritional perspective. Obesity, subjective, and objective aspects of eating behavior, in different clinical conditions and in the healthy population, addressing problem diagnosis and intervention with food and nutrition education programs will be studied with mixed methods of scientific investigation.
Project: Nutritional aspects in the health-disease process.Project description: The project investigates the nutritional aspects in the health-disease process, especially in patients with eating disorders, focusing on the diagnosis, prevention, promotion, therapy, and rehabilitation in different stages of the life cycle. Funding: FAPESP – Foundation for Research Support of the State of São Paulo – (Research Assistance – Regular) Other Financial Assistance.
Project: Nutritional status, oxidative and inflammatory stress in patients with malignant neoplasia.
Carry out clinical studies to investigate markers of nutritional status, oxidative and inflammatory stress in hospitalized patients and/or in conditions of organic stress, in malignant neoplasms, undergoing drug and/or surgical treatment.
Project: Energy metabolism and nutrient use.
In order to discover the energy expenditure and the oxidation rate of carbohydrates, proteins, and lipids for the planning and supply of nutrients for our population, both healthy and sick, clinical studies will be carried out on the energy metabolism of individuals obese, eutrophic, malnourished, and in climacteric women..